This report explores the clinical pictures of some diseases: For chronic heart failure, it is proposed that the existing regulations be relaxed for normal driving licences. For disorders of consciousness, there is an extensive description of the various aspects involved. The chapter on multiple sclerosis, clarifies and strengthens implementation critera. For intracranial tumours some specifications are made for benign tumours. Progress in the diagnosis and treatment of TIA and stroke justify a relaxation of the rules. Finally, there are descriptions and comments of autism spectrum disorders, inasmuch as this clinical picture affects the relationship with fitness to drive.