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DOCUMENT GENERAL INFORMATION

TITLE
Highly parallel cell culture in nanodrops, a new format for high content cell based toxicity
screening on Cell on Chips
  tox_drop_en.pdf (3.61 MB)
Document ID LIB222
Document type EC RTD Programmes projects / results
Issue date 31/12/2004
Document reference TOXdrop
Original language of the document English
Document produced by EC-Research and Innovation DG organisation visiting card
Document requested by EC-Research and Innovation DG organisation visiting card
Scientific domains
Policy domains
  • Health

DOCUMENT TEXT

Short description 
In modern life, we are exposed to a
huge variety of chemicals, both
natural and synthetic. It is crucial to
test these chemicals for any toxic
effects, to ensure they can be
produced, distributed and used in
safety. There is great pressure to
reduce the use of animals in toxicity
testing, both for ethical reasons and
because animal studies are not always
the best indicators of toxicity in
humans. One option is to use tests on
cultured cells. Although some such
‘cell-based assays’ have been
developed, they have not yet proved
as useful as was hoped. Developing
better methods is a priority.TOXdrop will develop innovative ‘cell on chip’ technology to
screen chemicals for toxicity, using cultured cells within tiny
‘nanodrops’ of culture fluid.
Abstract (focusing on the key recommendations)  TOXdrop will develop innovative ‘cell on chip’ technology to
screen chemicals for toxicity, using cultured cells within tiny
‘nanodrops’ of culture fluid.
The project will:
Develop a new type of substrate for microchips that will
allow toxicity testing of gaseous, liquid and solid
chemicals within thousands of the cellular nanodrops on
each chip
Create software for the collection and analysis of r ...

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