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TITLE Proton radiotherapy. Horizon scanning report   proton radiotherapy200917E.pdf (1.56 MB)
Title in the original language Protonenbestraling. Signalement  200917.pdf (1.58 MB)
Document ID LIB637
Document type Scientific article
Issue date 14/12/2009
Document reference ISBN:978-90-5549-786-7
Original language of the document Dutch
Full text available in EN (1.56 MB) and NL (1.58 MB)
Document produced by Health Council of the Netherlands organisation visiting card
Document uploaded by Mitra Javanmardi
Health Council of the Netherlands
Scientific domains
Policy domains
  • Health


Short description  This horizon scanning report from the Health Council of the Netherlands explores the potential advantages of proton radiotherapy for the treatment of patients with cancer, and the way this new radiotherapy modality could be introduced in the Dutch health care system. Starting from the specific physical principles of proton radiation, the perceived clinical benefits for different categories of tumours and patients are reviewed, based on the latest available scientific evidence. The scope for new treatment strategies and modalities with protons are discussed: improvement of tumour control (efficacy); reduction of side-effects (quality); and reducing the risk of secondary tumours (prevention of late side effects). Where evidence from prospective, controlled studies is lacking, methods to validate the outcomes from in silico comparative studies are discussed and proposed. Finally, prerequisites and preconditions for the clinical introduction of proton radiotherapy in the Netherlands are described.
Short description in the original language  Pro­to­nen­the­ra­pie lijkt op het terrein van de moderne ra­dio­the­ra­pie een veel­be­lo­ven­de ont­wik­ke­ling. Nader on­der­zoek, ge­kop­peld aan de be­han­de­ling van patiënten, moet uit­wij­zen voor welke tumoren de po­si­tie­ve ver­wach­tin­gen (beter be­han­del­re­sul­taat, minder bij­wer­kin­gen) ge­recht­vaar­digd zijn. Wordt be­slo­ten om in Ne­der­land fa­ci­li­tei­ten in te richten voor pro­to­nen­the­ra­pie, dan is een strak ge­re­gu­leer­de in­tro­duc­tie gewenst. Na een der­ge­lijk besluit duurt het ove­ri­gens nog enkele jaren voordat een pro­to­nen­fa­ci­li­teit in ons land vol­le­dig ope­ra­ti­o­neel kan zijn. Dit staat in het sig­na­le­ment Pro­to­nen­be­stra­ling dat de Ge­zond­heids­raad vandaag heeft aan­ge­bo­den aan de mi­nis­ter van Volks­ge­zond­heid, Welzijn en Sport.
Abstract (focusing on the key recommendations)  What is proton radiotherapy?
Treatment with protons (a type of subatomic charged particle) is a promising development in the field of modern radiation oncology. The physical properties of protons allow a better dose distribution when compared to current photon (X-ray) radiotherapy. This has the potential to minimize the dose to normal tissues and significantly reduce acute and late side effects. ...

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Abstract in the original language (focusing on the key recommendations)  Wat is protonenbestraling?
Behandeling met protonen (deeltjes met een massa en een lading) is een veelbelovende ontwikkeling op het terrein van de moderne radiotherapie. De fysische eigenschappen van protonen maken, in vergelijking met de gangbare fotonen (= hoogenergetische röntgenstraling), een betere fysische dosisverdeling mogelijk. Hierdoor kan de dosis in de normale weefsels minimaal gehoud ...

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