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DOCUMENT GENERAL INFORMATION

TITLE Benchmark dose method : derivation of health-based recommended exposure limits in new perspective   2003@06E.pdf (769.2 KB)
Document ID LIB296
Document type Scientific advisory body opinion/advice
Issue date 25/06/1905
Document reference 2003/06E
Original language of the document English
Document produced by Health Council of the Netherlands
Scientific domains
Policy domains
  • Health

DOCUMENT TEXT

Short description  Exposure to a chemical via air, water or food can result in the impairment of health,
depending on the degree of exposure and the toxicity of the substance. Health-based recommended exposure limits for a substance correspond with the highest estimated dose or concentration that does not lead to health impairment. To support the implementation of policy on industrial safety, environmental management and food safety, the Health Council derives such limits for specific substances. The Council also studies the methods employed to derive recommended exposure limits, and from time to time it advises modifying these methods to bring them into line with the latest developments in scientific knowledge.
This document, drawn up by the Health Council’s Committee on the Derivation of
Health-Based Recommended Exposure Limits, forms one such methodological advisory report.
Abstract (focusing on the key recommendations)  Benchmark dose method: health-based recommended exposure limits in new perspective

Exposure to a chemical via air, water or food can result in the impairment of health, depending on the degree of exposure and the toxicity of the substance. Health-based recommended exposure limits for a substance correspond with the highest estimated dose or concentration that does not lead to health impairment. T ...

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