The main trend in the EU-28 R&I performance is the emergence of a more nuanced divide between countries and regions. DG RTD with DG REGIO wish to gain insights into national experiences, with the aim to accelerate research and innovation performance in EU. The existing pockets of excellence can be a key driving force in Horizon Europe if better connected and developed. What key national measures beyond EU intervention can build strong national ecosystems, with a better articulation between FP and national R&I strategies? How improve the research management and administration and the responsiveness and flexibility of government? How enhance the uptake of Synergies at strategic, institutional and operational levels to ensure that coherent support of the entire R&I spectrum is the norm across EU in the Horizon Europe era?